GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs12748152 | 1 | rs56139710 | chr1:27269788 | ZDHHC18 | chr1:27153201-27182207:+ | 0.61 | 6.61 | 1.03E-10 | HDL cholesterol;Triglycerides;LDL cholesterol |
| THCA | cis | rs73086581 | 1 | rs56141565 | chr20:3998603 | C20orf194 | chr20:3229948-3388587:- | -0.19 | -3.36 | 0.000827 | Response to antidepressants in depression |
| THCA | cis | rs73086581 | 1 | rs56141565 | chr20:3998603 | MAVS | chr20:3827449-3856761:+ | -0.26 | -3.8 | 0.000162 | Response to antidepressants in depression |
| THCA | cis | rs56145559 | 1 | rs56145559 | chr2:73623439 | ALMS1P | chr2:73872046-73912692:+ | 0.7 | 10.8 | 1.8E-24 | Schizophrenia |
| THCA | cis | rs56145559 | 1 | rs56145559 | chr2:73623439 | NAT8 | chr2:73867850-73869537:- | 0.38 | 5.92 | 6.12E-9 | Schizophrenia |
| THCA | cis | rs7216064 | 1 | rs56148300 | chr17:65892752 | C17orf58 | chr17:65987218-65989765:- | 0.24 | 4.96 | 9.81E-7 | Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma |
| THCA | cis | rs7537765 | 1 | rs56153133 | chr1:11885647 | CLCN6 | chr1:11866207-11907674:+ | 0.16 | 3.51 | 0.000484 | QRS complex (12-leadsum) |
| THCA | cis | rs9309473 | 1 | rs56154726 | chr2:73721767 | ALMS1P | chr2:73872046-73912692:+ | 0.76 | 11.76 | 3.13E-28 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs56154726 | chr2:73721767 | NAT8 | chr2:73867850-73869537:- | 0.4 | 6.16 | 1.55E-9 | Metabolite levels |
| THCA | cis | rs3771570 | 1 | rs56156035 | chr2:242205955 | ANO7 | chr2:242127924-242164791:+ | 0.37 | 4.34 | 1.76E-5 | Prostate cancer |
| THCA | cis | rs3771570 | 1 | rs56156035 | chr2:242205955 | SEPT2 | chr2:242254723-242293439:+ | -0.28 | -4.27 | 2.35E-5 | Prostate cancer |
| THCA | cis | rs8030605 | 1 | rs56156930 | chr15:56485411 | MNS1 | chr15:56720929-56757335:- | -0.24 | -3.51 | 0.000493 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs8030605 | 1 | rs56156930 | chr15:56485411 | TEX9 | chr15:56657644-56738071:+ | -0.35 | -5.96 | 4.99E-9 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs9815354 | 1 | rs56158380 | chr3:41885588 | ULK4 | chr3:41288091-42003660:- | 1.04 | 19.01 | 1.99E-60 | Diastolic blood pressure |
| THCA | cis | rs56159542 | 1 | rs56159542 | chr19:19682971 | HAPLN4 | chr19:19366453-19384074:- | -0.31 | -5.17 | 3.51E-7 | Attention deficit hyperactivity disorder symptom score |